Superfluxin-thiamphenicol powder

Amide alcohol antibiotics. Mainly used for the treatment of livestock and poultry intestinal, respiratory tract and other bacterial infections and fish bacterial diseases.

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Introduction

Superfluxin-thiamphenicol powder

【Main ingredients]]Thiamphenicol

【Traits]]This product is white powder.

【Pharmacological action]]pharmacodynamics Thiamphenicol is an amide alcohol antibacterial drug with a broad-spectrum antibacterial effect, but the effect on gram-negative bacteria is stronger than that of gram-positive bacteria, and it is more effective for most enterobacteriaceae bacteria, including typhoid bacillus, paratyphoid bacillus, and large intestine.Elsie.Salmonella, highly sensitive to its sensitive gram-negative bacteria and Pasteuella, Brucella and so on. Sensitive Gram-positive bacteria are Bacillus anthracis, Streptococcus, Corynebacterium, Pneumococcus, Staphylococcus, etc. Chlamydia, Leptospira and Rickettsia are also sensitive to this product. It also has a considerable effect on anaerobic bacteria such as Clostridium tetani and actinomycetes. However, Mycobacterium tuberculosis, Pseudomonas aeruginosa and fungi are not sensitive to it.

pharmacokinetics This product is absorbed quickly and completely by internal administration. After absorption, it is widely distributed in various tissues in the body. Mainly excreted from the urine in its original form. The half-life in cattle and sheep is shorter than that of chloramphenicol, and the half-life in pigs is4.2Hours.

【drug interaction]] （1) Macroliids and linkosomes have the same target of action as this product, both of which are bacterial ribosomes.50SThe subunit binds and can produce antagonistic effects when combined.

（2) andBeta-When lactams are used together, they can produce antagonistic effect due to the rapid antibacterial effect of this product.

（3) Inhibitory effect on liver microsomal drug metabolizing enzymes, which can affect the metabolism of other drugs, increase blood drug concentration, enhance efficacy or toxicity, for example, can significantly prolong the anesthesia time of pentobarbital sodium.

【role and use]]Amide alcohol antibiotics. MainFor the treatment of livestock and poultry intestinal, respiratory tract and other bacterial infections and fish bacterial diseases.

【UsagewithDosage]]toThis product calculation. Internal administration: once, per1kgWeight, Livestock and Poultry33.3～66.7mgOne day.2times, use together2∼3Times.Mixed bait feeding: per150kgWeight, fish16.7gOne day.1times, use together3∼4Day.

【Adverse reaction]]（1) This product has hematological toxicity. Although it does not cause aplastic anemia, the reversible erythropoiesis inhibition caused by it is more common than chloramphenicol.

（2) This product has a strong immunosuppressive effect, about stronger than chloramphenicol6Times.

（3) Long-term oral administration can cause digestive disorders, vitamin deficiency or double infection symptoms.

（4) Embryo toxicity.

（5) Inhibitory effect on liver microsomal drug metabolizing enzymes, which can affect the metabolism of other drugs, increase blood drug concentration, enhance efficacy or toxicity, for example, can significantly prolong the anesthesia time of pentobarbital sodium.

【Precautions]]（12) Vaccination period or animals with severe immune function defects are contraindicated.

（22) Use livestock with caution during pregnancy and lactation.

（3) Renal insufficiency animals should reduce or extend the interval between doses.

【Drug rest period]]28Day; milk abandonment period7day; fish500The day.

[Specification]]15%

storage]Shade, seal, and store in a dry place.

【Executive standards]]Pharmacopoeia of the the People's Republic of China Beast2020One annual edition.