Lincomycin Hydrochloride Injection-Xinning

Lincan amine antibiotics. For gram-positive bacteria infection, can also be used for swine treponemal disease and mycoplasma infection.

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Animal Medicine

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Introduction

Xinning-Lincomycin Hydrochloride

【Main Ingredients 】Lincomycin Hydrochloride

[Character] This product is colorless to slightly yellow or yellowish green clear liquid.

[Pharmacological Effects] Pharmacodynamics Lincomycin belongs to lincomycin antibiotics and is a bacteriostatic agent. Sensitive bacteria include Staphylococcus aureus (including penicillin-resistant strains), Streptococcus, pneumococcus, Bacillus anthracis, swine erysipelas, some mycoplasma (Mycoplasma hyopneumoniae, Mycoplasma hyorhini, swine synovial sac mycoplasma), Leptospira and anaerobic bacteria (such as Fusobacterium, Clostridium, Clostridium tetanus tetanus tetanus tetanus tetanus, Clostri. It mainly acts on the 50S subunit of the bacterial ribosome and exerts its antibacterial effect by inhibiting the elongation of the peptide chain and affecting the synthesis of proteins.

Pharmacokinetics After intramuscular injection, the absorption was rapid, and the peak blood concentration of the drug was 6.25 µg/ml after a single intramuscular injection of 11 mg/kg in pigs. Plasma protein binding rate was 57% ~ 72%. Widely distributed in vivo, the apparent volume of distribution in pigs is 2.8L/kg. Widely distributed to a variety of body fluids, tissues (including bone), in which the highest concentration of liver, kidney, tissue drug concentration than the same period in serum concentrations of several times higher. It can enter the placenta, but it is not easy to pass through the blood-brain barrier, and it is difficult to reach the effective concentration of drugs in the cerebrospinal fluid during inflammation. It can be distributed to milk at the same concentration as plasma. Part of the drug is metabolized in the liver, and the original form of the drug and its metabolites are excreted through bile, urine and milk. The discharge of feces is delayed for several days, so it has an inhibitory effect on intestinal sensitive microorganisms.

[drug interactions] (1) when combined with gentamicin, such as staphylococcus, streptococcus and other gram-positive bacteria have a synergistic effect.

(2) combined with aminoglycoside and peptide antibiotics, may enhance the nerve-muscle junction block. In combination with erythromycin, there is an antagonistic effect, because of the same site of action, and the affinity of erythromycin to bacterial ribosomal 50S subunit is stronger than this product.

(3) It should not be combined with antidiarrheal drugs that inhibit intestinal peristalsis and contain white clay.

(4) with kanamycin, novobiocin and other incompatibility.

[function and use] lincan amine antibiotics. For gram-positive bacteria infection, can also be used for swine treponemal disease and mycoplasma infection.

[Usage and Dosage] Intramuscular injection: once, every 1kg of body weight, pig 0.033ml, once a day; Dogs and cats 0.033ml twice a day for 3-5 days.

[adverse reactions] with neuromuscular blocking effect.

[Precautions] Intramuscular injection may cause transient diarrhea or soft stool. Although rare, such as should take the necessary measures to prevent dehydration.

[drug withdrawal period] pig 2 days.

"Specifications" calculated by C18H34N2O6S 10ml:3g

[Storage] Closed preservation.

[Implementation Standard] "the People's Republic of China Veterinary Pharmacopoeia" 2020 Edition I